Ultrastructure of Adrenal Cortex of the Dog During Treatment With DDD2,3

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Abstract
Dogs were given 200 mg per kg per day of 2,2-bis (parachlorophenyl)-1,1-dichloroethane (DDD) by mouth. The adrenal glands were fixed in buffered osmium and embedded in Epon for electron microscopy. Twelve hours after a single dose of DDD, mitochondria in the zona fasciculata began to undergo dissolution. By 24 hours both the mitochondria and ergastoplasm of the zona fasciculata were essentially destroyed and only remnants of mitochondrial membranes remained. At 2 and 4 days the abnormalities in the zona fasciculata were similar but even more severe, and by 12 days the cells were shrunken, with abnormal nuclei, altered lipide, and sparse intracellular organelles. The zona glomerulosa also was abnormal with swollen mitochondria and abnormalities of lipide, but the degree of involvement was less than that in the zona fasciculata. After a 3-day period on DDD, 2 dogs were allowed to recover for 12 weeks, at which time the adrenal gland had returned almost to normal.

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