Carboxyl group (–CO2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications
- 28 July 2004
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry
- Vol. 14 (18) , 2781-2786
- https://doi.org/10.1039/b404964k
Abstract
A new approach to prepare surface-functionalized magnetic nanoparticles by synthesis of poly(methacrylic acid) (PMAA) coated maghemite nanoparticles in aqueous solution is reported. Maghemite (γ-Fe2O3) nanoparticles with an average diameter of 8 ± 2 nm were fabricated and subsequently coated with PMAA by emulsion polymerization. The FTIR study and thermal analysis confirmed the chemical adsorption of methacrylic acid on the maghemite nanoparticle surface, and suggested a symmetrical carboxylate bonding. The free carboxyl group of PMAA, which was verified by FTIR spectroscopy and zeta potential measurement, provided the site for immobilization of foreign molecules. The PMAA coated maghemite nanoparticles were demonstrated as potential magnetically targeted drug carriers by adsorbing an anti-cancer drug (carboplatin) via the ion–dipole interaction between CO2 − of PMAA and carboplatin.This publication has 33 references indexed in Scilit:
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