Increased excretion ofo-hydroxymandelic acid in phenylketonuria
- 1 August 1980
- journal article
- research article
- Published by Wiley in Journal of Mass Spectrometry
- Vol. 7 (8) , 349-353
- https://doi.org/10.1002/bms.1200070807
Abstract
o-Hydroxymandelic acid has been found in large amounts in the urine of patients with phenylketonuria by gas chromatography mass spectrometry selected ion monitoring. Using deuterated o-hydroxymandelic acid as an internal standard, five patients were found to excrete 150-340 ng mg−1 creatinine. This may be compared with the excretion of 4-16 ng mg−1 creatinine by normal subjects. Neither o-octopamine nor o-synephrine were found in urine under conditions by which 1 ng mg−1 creatinine would have been detected.Keywords
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