Sensitization and Antibody Formation in Monkeys Injected with Tubercle Bacilli in Paraffin Oil

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Abstract
Coulaud (1) has shown that the addition of paraffin to heat-killed tubercle bacilli promotes the sensitization of rabbits to tuberculin. Saenz (2) found that the solid paraffin could be replaced by liquid paraffin oil. He produced very intense and lasting sensitization in guinea pigs by subcutaneous or intramuscular injections of 1 cubic centimeter of paraffin oil containing a large amount of heat-killed and dried tubercle bacilli. Freund, Casals and Hosmer (3) observed that, both in the guinea pig and the rabbit, the addition of small amounts of paraffin oil to heat-killed tubercle bacilli augmented not only sensitization but also the formation of complement-fixing antibodies. The purpose of the present work was to determine whether paraffin oil containing heat-killed tubercle bacilli effectively sensitizes Macacus rhesus monkeys, a species said to be lacking in the capacity to develop cutaneous sensitization to tuberculin.

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