MannosylGlycodendritic Structure Inhibits DC-SIGN-Mediated Ebola VirusInfection in cis and in trans

Open Access

1 December 2003

journal article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 47 (12) , 3970-3972
https://doi.org/10.1128/aac.47.12.3970-3972.2003

Abstract

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

Keywords

This publication has 23 references indexed in Scilit:

Glycodendritic Structures Based on Boltorn Hyperbranched Polymers and Their Interactions with Lens culinaris Lectin
Bioconjugate Chemistry, 2003
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
The Journal of Experimental Medicine, 2002
Prevention of Influenza Pneumonitis by Sialic Acid–Conjugated Dendritic Polymers
The Journal of Infectious Diseases, 2002
C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans
Journal of Virology, 2002
DC-SIGN (CD209) Expression Is IL-4 Dependent and Is Negatively Regulated by IFN, TGF-β, and Anti-Inflammatory Agents
The Journal of Immunology, 2002
DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection
Immunity, 2002
Folate Receptor-α Is a Cofactor for Cellular Entry by Marburg and Ebola Viruses
Cell, 2001
Inhibition of Viral Adhesion and Infection by Sialic-Acid-Conjugated Dendritic Polymers
Bioconjugate Chemistry, 1999
Generation of Retroviral Vector for Clinical Studies Using Transient Transfection
Human Gene Therapy, 1999
Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.
Proceedings of the National Academy of Sciences, 1992