EFFECT OF ORAL SPIRONOLACTONE AND INTRAVENOUS CANRENOATE-K ON DIGOXIN RADIOIMMUNOASSAY

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (12) , 557-559
Abstract
Patients (20) receiving a constant maintenance therapy of digoxin preparations were selected and daily plasma digoxin concentrations were measured using the clinical assays .gamma.-coat 125I-digoxin radioimmunoassay. A single i.v. dose of canrenoate-K was given to 10 patients, thus producing after 5 min a rapid rise of plasma digoxin concentration which varied from 121.1-214.3% of the baseline value (100%). In 3 of these patients, plasma digoxin concentrations were measured serially over a period of 8 h and yielded digoxin levels of 81.5, 112.5 and 122.5% of the baseline value. The other 10 patients received an oral dose of 100 mg spironolactone twice a day and plasma digoxin determinations were carried out daily. Up to the 5th day, a continuous rise of average digoxin levels was found (on day 5, 181.0%) as long as digoxin and spironolactone were continued. From the 6th to the 9th day of therapy, average mean values remained fairly constant (on days 6-9, 168.9, 173.6, 170.8, 172.5%, respectively).

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