Intravenous Injection of Thalidomide in Pregnant Rabbits
- 15 July 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 153 (3733) , 310-311
- https://doi.org/10.1126/science.153.3733.310
Abstract
When administered orally to pregnant strain III rabbits, thalidomide is teratogenic to their fetuses. However, when the drug is injected intravenously to females of the same genetically controlled stock, it has no observable effect. This finding indicates that a metabolite of thalidomide formed in the intestinal tract may be the real teratogenic agent.This publication has 8 references indexed in Scilit:
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- OBSERVATIONS SUR LES REPERCUSSIONS TERATOGENES DE LA THALIDOMIDE CHEZ LA SOURIS ET LE LAPIN1962
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