Purification of nuclear antigens in Novikoff hepatoma.
- 1 April 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (4) , 1943-1946
- https://doi.org/10.1073/pnas.75.4.1943
Abstract
Nuclear antigen in [rat] Novikoff hepatoma chromatin was partially purified and characterized. As indicated by complement fixation assay, this antigen was present in chromatin of embryonic livers and several transplantable tumors. It was not detected in normal tissue chromatins of the same animals. For its immunological specificity this protein antigen (MW 45,000-60,000) had to be complexed with DNA. Preliminary experiments indicate that specific nuclear protein antigens are also present in human tissues and spontaneous malignancies.This publication has 24 references indexed in Scilit:
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