CIMETIDINE, AN H2-ANTIHISTAMINE, STIMULATES PROLACTIN SECRETION IN MAN
- 1 August 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 45 (2) , 367-370
- https://doi.org/10.1210/jcem-45-2-367
Abstract
Intravenous administration of cimetidine, a histamine (H2) receptor antagonist, provoked an immediate 2 to 3-fold rise in serum prolactin concentrations in 8 normal men; serum thyrotropin, groxwth hormone, thyroxine, and triiodothyronine were not significantly affected. Diphenhydramine, an Hiantagonist, was without effect on any of the hormones measured. The results suggest that histamine may have an important function in the regulation of prolactin secretion in man.Keywords
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