Overproduction of protein p53 contributes to simian virus 40-mediated transformation.
- 1 October 1986
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 6 (10) , 3531-3536
- https://doi.org/10.1128/mcb.6.10.3531
Abstract
The possible involvement of p53 overproduction in simian virus 40 (SV40) mediated transformation was studied by using the rat embryo fibroblast focus formation assay. Transformation by wild-type SV40 was enhanced to- to threefold by cotransfection of a plasmid overexpressing mouse p53. More significantly, such a plasmid could partially complement a transformation-defective deletion mutant of SV40. Hence, the ability of SV40 T antigen to induce high p53 levels may indeed be directly relevant to the viral transforming potential.This publication has 38 references indexed in Scilit:
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