In past years eight cases of syphilis of the stomach and two cases of syphilis of the colon have been reported from this clinic (LaRoque,1Pusch,2Williams3). We feel perfectly confident of the diagnosis of these cases and feel that they present the classic picture of advanced syphilitic involvement. We find, however, that there is wide divergence of opinion, from the view that the lesion is actually not syphilitic in nature to that of reporting nonspecific ulcers in a syphilitic individual as examples of this disease. The occurrence of another typical case prompts us to review our former experience and to present the subject particularly from the standpoint of diagnosis, microscopic appearance of the lesion, and treatment. In the first place we would emphasize the point that the lesion which we are discussing is an infiltrating one which involves varying amounts of the stomach and is located