Isodicentric X Chromosome in Myeloproliferative Disorders
- 1 January 1989
- journal article
- case report
- Published by S. Karger AG in Acta Haematologica
- Vol. 81 (3) , 152-154
- https://doi.org/10.1159/000205549
Abstract
Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.Keywords
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