Patterns of oncogene activation in human neuroblastoma cells
- 1 January 1997
- journal article
- review article
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 31 (1/2) , 25-31
- https://doi.org/10.1023/a:1005721027709
Abstract
Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.Keywords
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