Catalytic enantioselective addition of enol silanes to ketomalonate mediated by C2-symmetric bisoxazoline Lewis acid complexes
- 1 January 1999
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 16,p. 1505-1506
- https://doi.org/10.1039/a902227i
Abstract
A catalytic enantioselective addition reaction of silyl enol ethers to ketomalonate in the presence of C2-symmetric copper(II) bisoxazolines as catalysts is presented; the reaction has been studied for different ligands and substrates under various reaction conditions and proceeds in good yield and with ee’s >90% and a procedure for the preparation of an optically active hydroxy acid is shown.Keywords
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