Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
- 7 January 1997
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 7 (1) , 67-72
- https://doi.org/10.1016/s0960-894x(96)00583-5
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- The synthesis of thrombin inhibitor L-370,518 via an α-hydroxy-β-lactamTetrahedron Letters, 1996
- Crystal Structure of Human α-Thrombin Complexed with Hirugen and p-Amidinophenylpyruvate at 1.6 Å ResolutionArchives of Biochemistry and Biophysics, 1995
- Amide and α-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterizationBioorganic & Medicinal Chemistry, 1995
- Small-molecule inhibitors of thrombinPerspectives in Drug Discovery and Design, 1994
- Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profileTrends in Pharmacological Sciences, 1993
- Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide AThrombosis Research, 1993
- Rat model of arterial thrombosis induced by ferric chlorideThrombosis Research, 1990
- CHAIN — A crystallographic modeling programJournal of Molecular Graphics, 1988
- Crystallographic R Factor Refinement by Molecular DynamicsScience, 1987