Medical Shock: Abnormal Biochemical Changes in Patients with Severe, Acute Medical Illnesses, with and without Peripheral Vascular Failure

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Abstract
Twelve patients suffering chiefly from infection, cardiovascular disease, or poisoning were studied. The biochemical changes found were: hyperglycemia, lactacidemia, fall in bicarbonate reserve, reduction of oxygen saturation of peripheral blood, frequent elevation of [alpha] amino nitrogen of blood plasma. There was usually a lengthening of the prothrombin time, and an elevation of the icterus index. There was a marked correlation between the degree of peripheral vascular failure and the biochemical changes.

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