Studies on niacin biosynthesis from 3-hydroxy-anthranilic acid in streptozotocin diabetic rats in vivo and in vitro.
- 1 January 1976
- journal article
- research article
- Published by Center for Academic Publications Japan in Journal of Nutritional Science and Vitaminology
- Vol. 22 (3) , 175-179
- https://doi.org/10.3177/jnsv.22.175
Abstract
Biosynthesis of niacin from 3-hydroxyanthranilic acid (3-OHAA) in normal and streptozotocin diabetic rats was studied in vivo and in vitro. Streptozotocin (SZ) diabetic rats excreted lesser quantities of 3-OHAA, quinolinic acid, niacin and N1-methylnicotinamide (NMN) in their urines following 3-OHAA administration than corresponding normal rats. In vitro studies indicated that SZ diabetic livers form less quinolinic acid from 3-OHAA than normal livers. This may be due to elevated picolinic carboxylase activity in the livers of SZ diabetic rats.This publication has 6 references indexed in Scilit:
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