ISOLATION AND CHARACTERIZATION OF AND SOME OBSERVATIONS ON POISONING BY BUFADIENOLIDES FROM COTYLEDON-ORBICULATA L VAR ORBICULATA

  • 1 January 1985
    • journal article
    • research article
    • Vol. 52  (1) , 21-24
Abstract
The approximate LD50 and cumulative effect of 4 bufadienolides, isolated from C. orbiculata, were determined in guinea-pigs. Two of the bufadienolides proved to be mildy cumulative. One of the mildy cumulative bufadienolides induced subacute intoxication with some signs of krimpsiekte when injected intravenously into sheep over 13 days. In the sheep, the paralysis was accompanied by signs of malaise, such as electrocardiographic changes and ruminal stasis.

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