WEIGHT-LOSS AND METABOLIC CHANGES OF MORBIDLY OBESE PATIENTS AFTER GASTRIC PARTITIONING OPERATION

  • 1 January 1984
    • journal article
    • research article
    • Vol. 96  (3) , 545-549
Abstract
Weight loss, alterations in basal metabolic rate, and utilization of body fat, carbohydrate, and protein substrates were studied in 9 patients before operation and 3 and 12 mo. after gastric partitioning operation for morbid obesity. Respiratory O consumption and CO2 excretion measurements were taken 3 consecutive mornings by the open circuit-Scholander technique. Measurements of urine urea nitrogen were made from 24-h urine collections. Basal metabolic rate and utilization of fat, carbohydrate, and protein were calculated in kcal per minute by indirect calorimetry. Initial body weight was 124.5 .+-. 19.0 kg (mean .+-. SD). The weight losses between measurements at months 0 and 3 and at months 3 and 12 were 20.8 .+-. 4.6 kg and 2.7 .+-. 8.4 kg, respectively. Total weight loss between months 0 and 12 was 23.5 .+-. 8.3 kg (19.3% .+-. 7.4%). At 3 mo. the fraction of basal metabolic rate contributed by carbohydrate (P < 0.05) and protein (P < 0.01) utilization decreased significantly, while that contributed by fat increased (P < 0.05). Between months 0 and 12 there was no significant difference in protein or carbohydrate utilization, but fat utilization increased (P < 0.01). Gastric partitioning operation resulted in an initial rapid body weight loss over 3 mo. with a sustained reduction over 1 yr; there was a metabolic utilization shift to fat with carbohydrates and protein sparing; no metabolic parameter was predictive of weight loss; and temporally, the rapid weight loss was paralleled by a significant metabolic utilization shift and the sustained loss was paralleled by a stabilization of this shift.

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