NASAL POLYPOSIS WITH STROMAL ATYPIA - REVIEW AND FOLLOW-UP-STUDY OF 14 CASES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 100  (4) , 224-226
Abstract
The clinical, microscopical and gross pathological features of 14 cases of intranasal and paranasal sinus polyposis with unusual stromal cell atypia were described. In gross appearance, the lesions were polypoid, translucent masses, similar to the usual nasal polyp. Although clinically the lesions were indicative of allergic and inflammatory nasal polyposis, microscopical examination showed numerous large, often pleomorphic histiocytes or facultative fibroblasts that were suggestive of sarcomatous, malignant degeneration. Diagnoses by the original contributing pathologists included embryonal rhabdomyosarcoma, stromal neoplasia and juvenile nasopharyngeal angiofibroma. Follow-up data showed no evidence of neoplasia, despite the remarkable cytological changes found in the stroma. The stromal atypia most likely represents a reactive phenomenon secondary to inflammation.

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