PROTEIN AND DNA LEVELS IN THE SUBMANDIBULAR SALIVARY GLANDS OF ISOPROTERENOL STIMULATED MICE

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Abstract
The DNA and soluble and sedimental protein levels were studied in isoproterenol stimulated mouse .submandibular salivary glands over a period of 200 h. Hypertrophy, the predominant cellular phenomenon following chronic isoproterenol treatment, was assoeiated with a marked elevation of 14C-Icucine incorporation into the buffer soluble protein fraction and a less pronounced isotope incorporation into the sedimental sub-cellular fraction as well as continued DNA synthesis. These findings are contrary to the accepted definitions of hypertrophy which preclude continued DNA synthesis. A suggestion is made, therefore, that in the system used the polyploidy associated with the hypertrophy involves DNA synthesis.