Effects of Cobalt on Activity of Sheep Erythropoietin in Rat Kidney Homogenates.

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Abstract
Summary Rat kidney homogenates were found to inactivate sheep erythropoietin. This inactivation was partially prevented by addition of rather high concentrations of cobalt to the kidney suspensions before homogenization. Several dosages of cobalt alone or in combination with a rat kidney homogenate were tested in polycythemic mice and an unusually high dose was required to produce a significant increase in Fe50) incorporation in red cells. The recovery of erythropoietin from normal kidney homogenates was markedly increased by addition of an amount of cobalt which had in itself only a slight erythropoi-etic effect. The mechanism for this effect of cobalt as it relates to a possible antagonism of a renal erythropoietic inhibitory factor is discussed.

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