Minor products from the reaction of (+) and (−) benzo[a]-pyrene-anti-diolepoxide with DNA
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 2 (6) , 553-558
- https://doi.org/10.1093/carcin/2.6.553
Abstract
The reaction of [the carcinogen] trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BP-diolepoxide) with deoxyguanosine was studied. In addition to the expected N2-guanine derivative minor products resulting from reaction at the O6 and 7-positions were identified. Reaction of racemic, (+) or (-) BP-diolepoxide with [14C] and [3H]purine labeled DNA allowed same products to be identified and their yields estimated. The O6 and 7-guanine products were apparently derived mainly from reaction of the (-)isomer. The 7-substituted guanine derivative in DNA was unstable, undergoing spontaneous release of the substituted guanine or imidazole ring opening.This publication has 18 references indexed in Scilit:
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