Fluorinated benzamide neuroleptics. 1. Radiosynthesis of (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2[F‐18]fluoroethyl)‐2‐methoxybenzamide: A potential fluorine‐18 labeled PET radiotracer for dopamine D2 receptors
- 1 May 1990
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 28 (5) , 609-616
- https://doi.org/10.1002/jlcr.2580280511
Abstract
The synthesis of a tosylate precursor for the radiosynthesis of a potential PET radiotracer, (S)‐N‐[(1‐ethyl‐2‐pyrrolidinyl)methyl]‐5‐(2‐[18F]fluoroethyl)‐2‐ methoxybenzamide is reported. Reaction of 18F‐fluoride with the tosylate provides the radiolabeled product in 10–25% yield. Specific activity of the radiotracer varied between 600–800 Ci/mmol after purification of the product mixture by reverse phase HPLC.Keywords
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