IgA class reticulin antibodies in relatives of patients with coeliac disease.
Open Access
- 1 August 1977
- Vol. 18 (8) , 647-650
- https://doi.org/10.1136/gut.18.8.647
Abstract
IgA class reticulin antibodies were not found in patients with Crohn's disease, ulcerative colitis, and hiatus hernia despite a significant incidence of IgG class reticulin antibodies. None of 56 normal healthy subjects was positive. In contrast, 13 (76%) of the sera from 17 patients with coeliac disease on normal diet were positive for IgA class antibodies as were 19 (20%) of 93 first degree relatives. Seventy-three relatives underwent jejunal biopsy. Grade III (flat) histology was found in 13 and, of these patients, 10 (77%) showed IgA class reticulin antibody in their serum. It is suggested that determination of IgA class reticulin antibodies was a useful test to determine which relative must be biopsied.This publication has 13 references indexed in Scilit:
- Anticonnective tissue and other antitissue 'antibodies' in the sera of patients with coeliac disease compared with the findings in a mixed hospital population.Journal of Clinical Pathology, 1976
- Studies on the nature and significance of connective tissue antibodies in adult coeliac disease and Crohn's diseaseGut, 1974
- Types of `reticulin' antibodies detected in human sera by immunofluorescenceJournal of Clinical Pathology, 1973
- Autoantibodies in children with coeliac disease.1973
- ANTI-RETICULIN ANTIBODIES IN CHILDHOOD CŒLIAC DISEASEThe Lancet, 1971
- AUTOANTIBODIES TO RETICULIN IN PATIENTS WITH IDIOPATHIC STEATORRHŒA, CŒLIAC DISEASE, AND CROHN'S DISEASE, AND THEIR RELATION TO IMMUNOGLOBULINS AND DIETARY ANTIBODIESThe Lancet, 1971
- TISSUE ANTIBODIES IN DERMATITIS HERPETIFORMIS AND ADULT CŒLIAC DISEASEThe Lancet, 1971
- Studies of the Familial Nature of Celiac Sprue Using Biopsy of the Small IntestineNew England Journal of Medicine, 1965
- Microdroplet Assay of Human Serum CytotoxinsNature, 1964
- SIMPLE CAPSULE FOR MULTIPLE INTESTINAL BIOPSY SPECIMENSThe Lancet, 1964