Temporal relationships in the effects of protein‐free diet on the activities of rat liver branched‐chain ketoacid dehydrogenase complex and kinase

Abstract
Feeding rats 0% casein diet decreased liver activities of branched‐chain ketoacid dehydrogenase complex (active form) and of activator protein (complete within 4 days), and increased activity of branched‐chain ketoacid dehydrogenase kinase (complete within 9–10 days). Refeeding normal diet to rats fed 0% casein diet for 10 days resulted in a rapid and partial (approx. 50%) reversal of the above effects within 24 h; complete reversal required 20–30 days of refeeding.