Transgenic analysis of thymocyte signal transduction
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Immunology
- Vol. 2 (1) , 20-27
- https://doi.org/10.1038/nri703
Abstract
This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide-binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.Keywords
This publication has 79 references indexed in Scilit:
- MAP-kinase signaling pathways in T cellsCurrent Opinion in Immunology, 2001
- Control of pre-T cell proliferation and differentiation by the GTPase Rac-1Nature Immunology, 2000
- Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte developmentEuropean Journal of Immunology, 2000
- Inhibition of Rho at different stages of thymocyte development gives different perspectives on Rho functionCurrent Biology, 1999
- Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte PrecursorsImmunity, 1999
- THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENTAnnual Review of Immunology, 1999
- The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive ThymocyteCell, 1996
- The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytesCurrent Opinion in Immunology, 1996
- Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic miceJournal of Immunological Methods, 1995
- Functional dissection of the lck proximal promoter.Molecular and Cellular Biology, 1992