Influence of background and absorption correction on nuclear quantification of left ventricular end-diastolic volume

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Abstract
Left ventricular (LV) end-diastolic volume (EDV) was determined in ml by equilibrium radionuclide ventriculography (MUGA) in 38 patients [with congenital or acquired heart disease] and in 15 normal individuals by applying corrections for background (BC), LV blood self-absorption and for absorption by the thoracic and LV walls. Volume calibration was performed by measuring a syringe containing the patient''s venous blood with the .gamma.-camera. Single plane cineventriculography (CVG) served as the reference method. Without absorption correction, LV volume values were underestimated by a factor of 3.6 on the average. Several background models (uniform, parabolic or no background) were investigated. Without BC, EDV was overestimated and with uniform BC, EDV was underestimated. EDV calculated using a parabolic BC with a correction for absorption yielded the best correlation (r = 0.96) with volumes obtained by CVG.