Synthesis of (2S,5S,4R)-2,5-diamino-3,3-difluoro-1,6-diphenylhydroxyhexane: the core unit of a potent HIV proteinase inhibitor
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 110-112
- https://doi.org/10.1039/c39910000110
Abstract
The coupling of the novel pseudo-symmetrical dipeptide mimic 1a, synthesized via Boc-L-phenylalaninol, with Z-L-valine led to a very potent inhibitor of the HIV proteinase.Keywords
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