Studies on positive inotropic agents. I. Synthesis of 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone and related compounds.
- 1 January 1984
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 32 (6) , 2100-2110
- https://doi.org/10.1248/cpb.32.2100
Abstract
Many (1-piperazinyl)-2(1H)-quinolinone derivatives were synthesized and examined for positive inotropic activities on the canine heart. Among them, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone a very potent activity.This publication has 1 reference indexed in Scilit:
- Cardiotonic activity of amrinone--Win 40680 [5-amino-3,4'-bipyridine-6(1H)-one].Circulation Research, 1979