Human γ‐interferon expression in the mammary gland of transgenic mice
- 15 March 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 319 (1-2) , 181-184
- https://doi.org/10.1016/0014-5793(93)80063-z
Abstract
Transgenic mice carrying a hybrid gene consisting of ovine β-lactoglobulin gene sequences and human γ-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU/ml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male.Keywords
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