Effect of RMI 81968 a Combined Alpha- and Beta-Adrenergic Receptor Blocking Agent, on Histamine-Induced Bronchoconstriction in the Dog
- 1 January 1980
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 20 (2) , 111-114
- https://doi.org/10.1159/000137352
Abstract
The interaction of propranolol and RMI 81968 on histamine-induced bronchoconstriction was studied in the anesthetized dog using the respiratory overflow technique of Konzett and Rössler. Propranolol, 3 and 10 μmol/kg i.v., enhanced histamine-induced bronchoconstriction. In contrast, RMI 81968, at 10 or 30 μmol/kg i.v., had no effect in this test. It is believed that the α-receptor blocking component of RMI 81968 prevents the bronchoconstriction induced by β-adrenergic receptor blockade. The results of this study suggest that RMI 81968 is less likely than propranolol to produce bronchoconstriction in asthmatic patients.Keywords
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