BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
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- 14 September 2001
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5537) , 2108-2111
- https://doi.org/10.1126/science.1061965
Abstract
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.Keywords
This publication has 26 references indexed in Scilit:
- RIPping Tyrosine Kinase Receptors ApartScience, 2001
- B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune ResponsesMolecular and Cellular Biology, 2001
- Regulation of the T-Independent Humoral Response by TACIImmunity, 2001
- The TNF and TNF Receptor SuperfamiliesCell, 2001
- B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1Proceedings of the National Academy of Sciences, 2000
- Identification and Characterization of a Novel Cytokine, THANK, aTNF Homologue That ActivatesApoptosis, Nuclear Factor-κB, and c-Jun NH2-Terminal KinaseJournal of Biological Chemistry, 1999
- Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13Genomics, 1995
- The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and deathCell, 1994
- A single autosomal gene defect severely limits IgG but not IgM responses in B lymphocyte‐deficient A/WySnJ miceEuropean Journal of Immunology, 1992
- Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ miceEuropean Journal of Immunology, 1991