EMPIRICAL POWER OF 3 PRELIMINARY METHODS FOR ORDERING LOCI
- 1 December 1988
- journal article
- research article
- Vol. 43 (6) , 964-970
Abstract
We empirically estimated the power of three methods for ordering loci within a known linkage group. Estimates of pairwise recombination fractions and correlation coefficients were obtained from data on 50 replicates of 50 and 100 pedigrees by using a likelihood method (LIPED; Ott 1974) and the sib-pair test. Locus order then was determined using seriation, multidimensional scaling, and the product of recombination frequencies. Overall, the multidimensional scaling method was less powerful than either seriation or the product of recombination frequencies. The latter two methods were approximately equally powerful. As expected, the power of the sib-pair test was less than half that of the likelihood method.This publication has 10 references indexed in Scilit:
- A major simplification in the preliminary ordering of linked lociGenetic Epidemiology, 1988
- MULTIPOINT GENE-MAPPING USING SERIATION .1. GENERAL-METHODS1987
- Construction of multilocus genetic linkage maps in humans.Proceedings of the National Academy of Sciences, 1987
- Crossover Counts and Likelihood in Multipoint Linkage AnalysisMathematical Medicine and Biology: A Journal of the IMA, 1986
- Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences, 1984
- Genetic Analysis Workshop II: summary.1984
- The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.1983
- Linkage mapping from pair-wise recombination dataHeredity, 1977
- Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.1974
- The investigation of linkage between a quantitative trait and a marker locusBehavior Genetics, 1972