MONOCYTE CHEMOTAXIS IN LEUKEMIA PATIENTS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 95  (4) , 609-615
Abstract
Monocyte chemotaxis was studied in 35 patients with ALL [acute lymphocytic leukemia], 6 with CLL [chronic lymphocytic leukemia], 6 with AML [acute myelogenous leukemia] and 10 with CML [chronic myelogenous leukemia], before beginning chemotherapy. Function was contrasted to age-matched control groups. Significant inhibition of chemotaxis was seen in patients with ALL (P < 0.001) and CLL (P < 0.01), whereas function in CML and AML patients was not significantly depressed. The deficient monocyte chemotaxis was not due merely to decreased percentages of peripheral blood monocytes. In addition to numerical deficiencies in monocyte numbers, qualitative deficiencies in monocyte function exist in patients with ALL and CLL. [Monocyte cellular function may be one of the first immunologic functions altered in patients with progressing neoplasms, often before leukopenia or a large tumor mass develops].

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