Effect of alpha-methyl-dopa on heart and pulmonary arteries of hypoxic mice
- 1 October 1965
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 209 (4) , 702-704
- https://doi.org/10.1152/ajplegacy.1965.209.4.702
Abstract
Fifty mice were placed in an atmosphere of 10% oxygen and sacrificed at intervals. Twenty-one of the animals were simultaneously given methyl-dopate-HCI. Hypoxic control mice developed medial hyperplasia in small pulmonary arteries and right ventricular cardiac hypertrophy. These abnormalities did not develop in the drug-treated animals.Keywords
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