EFFECT OF A SULFHYDRYL INHIBITOR ON INVITRO BONE-MARROW COLONIES (CFU-C)

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (9-10) , 335-337
Abstract
A dose-related increase in the number of in vitro colony-forming units, CFU-c [granulocytic progenitor cells] was observed in mouse bone marrow cell suspensions following the administration of the sulfhydryl inhibitor, sodium iodoacetate. No effect on CFU-s [pluripotential stem cells] was observed at the dosages and the periods selected for examination. Direct exposure of marrow cells in vitro to various concentrations of iodoacetate did not influence colony formation.