Glucocorticoids Suppress Formation of Erythroid Colonies Cultured from Human Fetal Liver and Umbilical Cord Blood
- 1 January 1982
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 169 (1) , 63-66
- https://doi.org/10.3181/00379727-169-41308
Abstract
The effect of glucocorticoids on erythroid colony formation in vitro was studied in plasma clot and methylcellulose culture of human fetal liver and umbilical cord blood. At concentrations varying from 10-10 to 10-6 M, dexamethasone and hydrocortisone caused 25-90% reduction in the number of erythroid colonies present after 5-14 days of incubation. This suppression of erythroid colony production by glucocorticoids was not accompanied by an alteration in the ratio of .gamma.- and .beta.-globin chains synthesized by the erythroid cells.This publication has 14 references indexed in Scilit:
- In Vitro Culture of Erythroid Colonies from Human Fetal Liver and Umbilical Cord BloodBritish Journal of Haematology, 1979
- Dexamethasone induces irreversible G1 arrest and death of a human lymphoid cell lineJournal of Cellular Physiology, 1979
- GLUCOCORTICOID-MEDIATED INHIBITION OF ERYTHROID COLONY FORMATION BY MOUSE BONE-MARROW CELLS1979
- Differential response of early erythropoietic and granulopoietic progenitors to dexamethasone and cortisone.The Journal of Experimental Medicine, 1979
- Inhibition of dimethyl sulfoxide-stimulated Friend cell erythrodifferentiation by hydrocortisone and other steroids.Proceedings of the National Academy of Sciences, 1978
- Human erythroid burst-forming unit: T-cell requirement for proliferation in vitro.The Journal of Experimental Medicine, 1978
- Cooperative erythropoietic assay of several steroid metabolites in polycythemic miceSteroids, 1977
- Steroids and hematopoiesis I. The effect of steroids on in vitro erythroid colony growth: Structure/activity relationshipsJournal of Cellular Physiology, 1976
- Mechanisms of Prednisolone Action in ErythropoiesisEndocrinology, 1967
- Use of Mild Plethora to Demonstrate an Erythropoietic Effect from Small Amounts of AndrogensExperimental Biology and Medicine, 1965