An Efficient Direct α-Alkylation of Ketones with Primary Alcohols Catalyzed by [Ir(cod)Cl]2/PPh3/KOH System without Solvent
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- 13 December 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (1) , 72-73
- https://doi.org/10.1021/ja037552c
Abstract
α-Alkylation of ketones was successfully achieved by the reaction of ketones with alcohols catalyzed by iridium complexes in the presence of a small amount of base. For example, 2-octanone was allowed to react with butanol under the influence of [Ir(cod)Cl]2/PPh3/KOH to give 6-dodecanone in good yield. The reaction was found to proceed by using a 1:1 mixture of ketone and alcohol without use of any solvent.Keywords
This publication has 3 references indexed in Scilit:
- Catalytic Electronic Activation: Indirect “Wittig” Reaction of AlcoholsAngewandte Chemie International Edition in English, 2002
- Development of a Highly Efficient Catalytic Method for Synthesis of Vinyl EthersJournal of the American Chemical Society, 2002
- Iridium-Catalyzed Transfer Hydrogenation of α,β-Unsaturated and Saturated Carbonyl Compounds with 2-PropanolThe Journal of Organic Chemistry, 2001