A Sensitive Spectrophotometric Method for the Determination of Some Imidazoline Derivatives by 2,6-Dichlorophenol-Indophenol

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Abstract
A new and highly sensitive method is presented for the spectrophotometric determination of four imidazoline derivatives: antazoline hydrochloride, tolazoline hydrochloride, xylometazoline hydrochloride and naphazoline nitrate. The method is based on the reaction of the corresponding drug base with 2,6 - dichlorophenol -indophenol (DGPIP) in chloroform to give a blue chromogen exhibiting a maximum at 588 - 603nm. The method could be applied for the quantitative determination of the above drugs either pure or in their pharmaceutical preparations (tablets and nasal drops). The results obtained are accurate and have good reproducibility.