Assessment of Bone Mineral Content and Bone Mass by Non-Invasive Radiologic Methods
- 1 November 1986
- journal article
- review article
- Published by SAGE Publications in Acta Radiologica. Diagnosis
- Vol. 27 (6) , 609-617
- https://doi.org/10.1177/028418518602700601
Abstract
Methods for quantitative determination of bone mineral and bone mass in normal subjects and in patients with metabolic bone disorders can be measured by the Compton scattering technique, the neutron activation analysis, by measurement of metacarpal bone mass, by single and dual photon absorptiometry, and by quantitative computed tomography. Measurement on metacarpal bone (radiogrammetry) seems to be able to distinguish between resorption and/or new bone formation at the periosteal and/or endosteal surface. The intraindividual observer variation on combined cortical thickness (D—d), cortical area (D2–d2), metacarpal bone mass (D2–d2)/D2 varies from 0.7 to 2.5 per cent and the interindividual observer variation from 1.0 to 5.8 per cent. Single photon absorptiometry measures bone mineral content in the forearm with great precision. The reproducibility using repeated measurements and automatic selection of the measuring area is about one per cent and can be used to follow changes in mineral content with time in patients with metabolic bone diseases. The dual photon absorptiometry may be used for measurements of bone mineral content in lumbar spine, in the femoral neck and measurement of total body calcium with an accuracy of less than 6 per cent and a precision below 3 per cent. Quantitative computed tomography has the ability to measure trabecular and cortical bone both centrally and peripherally. Using CT scanning, scanner related changes with time (day-to-day variation ± 4%), patient repositioning (less than 1.5%), and fat concentration (residual uncertainty of approximately 1/6 of the biologic variation) are important factors influencing the accuracy and reproducibility of the values of the measured bone mineral content. The method is very useful in studies of skeleton changes in metabolic bone diseases.Keywords
This publication has 58 references indexed in Scilit:
- Getrennte Messung von Kompakta- und Spongiosadichte mit einem Transversal-Rotations-ScannerRöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 1985
- DEVELOPMENT OF QUANTITATIVE CT METHODS FOR BONE AND SOFT TISSUE EVALUATIONSJournal of Computer Assisted Tomography, 1983
- FUTURE ADVANCED CT TECHNOLOGY FOR BONE AND TISSUE DENSITOMETRYJournal of Computer Assisted Tomography, 1982
- Relations of Bone Mineral Content, Ash Weight and Bone MassClinical Orthopaedics and Related Research, 1980
- A NEW INSTRUMENT FOR DETERMINATION OF BONE MINERAL IN THE LUMBAR SPINENuclear Medicine Communications, 1980
- International Workshop on Bone and Soft Tissue Densitometry Using Computed Tomography1Journal of Computer Assisted Tomography, 1979
- A Technique for Simultaneous Dual Energy SJournal of Computer Assisted Tomography, 1979
- Bone loss in diabetes: Effects of metabolic stateDiabetologia, 1979
- Bone Mineral Content in Chronic Renal Failure during Long‐Term Treatment with 1α‐HydroxycholecalciferolActa Medica Scandinavica, 1978
- Effects of the Polyenergetic Character of the Spectrum of 125I on the Measurement of Bone Mineral ContentInvestigative Radiology, 1973