The responses of carotid vascular strips from spontaneously hypertensive and normotensive rats
- 1 January 1980
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 58 (1) , 53-59
- https://doi.org/10.1139/y80-010
Abstract
The responses to noradrenaline (NA, norepinephrine) and KCl of carotid arterial strips from spontaneously hypertensive rats (SHR) and 3 strains of normotensive rats (NR) were compared using tissues obtained from young (5-7 wk) or older (15-17 wk) rats. The maximum responses and sensitivity of strips from SHR were less than those of NR in both age groups. Relaxation of maximum NA-induced responses was consistently faster, and relaxation of KCl-induced responses generally slower with strips from SHR. Carotid strips from young SHR showed a greater dependence on extracellular Ca in their responses to NA and a lesser dependence in their KCl-induced responses than tissues from NR. The smooth muscle of carotid arteries from SHR differs intrinsically from that of NR and the differences in vascular responses may be related to altered excitation-contraction processes in the SHR.This publication has 1 reference indexed in Scilit:
- Vasoconstrictor hyperresponsiveness: An early pathogenic mechanism in the spontaneously hypertensive ratEuropean Journal of Pharmacology, 1978