Amino-Acid Sequence of Toxin I from Anemonia sulcata

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Abstract
Toxin I from A. sulcata, a major component of the sea anemone venom, consists of 46 amino acid residues which are linked by 3 disulfide bridges. The [14C]carboxymethylated polypeptide was sequenced to position 29 by automated Edman degradation. The remaining sequence was determined from cyanogen bromide peptides and from tryptic peptides of the citraconylated [14C]carboxymethylated toxin. Toxin I is homologous to toxin II from A. sulcata and to anthopleurin A, a toxin from the sea anemone Anthopleura xanthogrammica. These constitute a new class of polypeptide toxins. No significant homologies exist with toxin III from A. sulcata nor with known sequences of neurotoxins or cardiotoxins of various origin.