IMMUNE REACTIVITY OF CELLS FROM LONG-TERM RAT RENAL ALLOGRAFT SURVIVORS

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Abstract
Lewis rats receiving an LBN [Lewis .times. Brown-Norway] kidney allograft demonstrated no signs of rejection if they were pretreated with donor spleen cells and antiserum reactive with the donor alloantigen. The cellular reactivity of long-term kidney allograft survivors were examined. Normal proliferative and cytolytic responses were obtained with spleen cells from long-term survivors, in marked contrast to the diminished responses of cells from neonatally tolerant rats or the heightened cytolytic response of cells from rats that had rejected a renal allograft. Serum from long-term renal allograft survivors and serum obtained from rats at the time of transplantation did not suppress proliferative or cytolytic responses of normal cells. Long-term renal allograft survivors apparently possess the precursors of those cells which are responsible for proliferative and cytolytic responses in mixed leukocyte cultures, but they have not been sensitized to their renal allograft.

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