Alterations in Antibody Response Induced by Chronic Inhalation of SO2and Carbon
- 1 July 1972
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 25 (1) , 45-50
- https://doi.org/10.1080/00039896.1972.10666134
Abstract
Mice were exposed to low concentrations of carbon, SO2, and carbon plus SO2 In an attempt to determine the effect of chronic exposures on the immunological defense mechanism. Carbon alone or in combination with SO2 caused a progressive decrease in overall ability of the animals to form antibody. Reduction of antibody formation occurred in mice exposed to 2.00 ppm SO2 for 192 days. An enhancement of antibody production occurred in mediastinal lymph nodes after 102 and 135 days of exposure, but this effect was being reversed by 192 days. An unexpected enhancement of antibody production, especially in the spleen, occurred in mice exposed to SO2 alone for 135 days. This adjuvant activity had faded by 192 days, when an overall suppression of antibody response was seen, though not to the degree observed in the animals exposed to carbon.Keywords
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