Blood Viscosity, Finger Systolic Pressure and Effect of Dazoxiben Treatment in Primary Vasospastic Disease

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Abstract
Whole blood viscosity, plasma viscosity, erythrocyte deformability, and finger systolic pressure (FSP) were measured in ten patients with primary vasospastic (Raynaud's) disease before and after a controlled double-blind prospective trial involving dazoxiben (a thromboxane inhibitor, Pfizer). Five of the patients were assigned to dazoxiben and five to placebo. Before treatment, the FSP at 10 °C in the patient groups was significantly lower than that in a normal reference group, but all rheologic variables, measured at 37 and 10 °C, were normal. There was no significant correlation between FSP and rheology. Dazoxiben did not yield any subjective relief or give any objective effect.