The Interaction of Anthralin, Salicylic Acid and Zinc Oxide in Pastes

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Abstract
When anthralin is applied with a zinc oxide paste as vehicle its antipsoriatic activity decreases in less than 3 weeks. Laboratory experiments make it probable that this deterioration is due to an interaction between anthralin and hydrolyzed zinc oxide molecules and simultaneous oxidation of anthralin into inactive 1,8-dihydroxyanthraquinone and other still unknown substances. The addition of salicylic acid partially inhibits these inactivation processes. The soft zinc oxide paste used in the clinical trials gave results that were as good as those of a stiffer zinc oxide paste and is easier to prepare and to apply.

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