Crossed cerebellar and uncrossed basal ganglia and thalarnic diaschisis in Alzheimer's disease

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Abstract
We detected croased cerebellar as well as uncrossed basal ganglia and thalamic diaschisis in Alzheimer's disease by positron emission tomography (PET) using 18F-fluorodeoxyglucose. We studied a series of 26 consecutive, clinically diagnosed Alzheimer cases, including 6 proven by later autopsy, and compared them with 9 age-matched controls. We calculated asymmetry indices (AIs) of cerebral metabolic rate for matched left-right regions of interest (ROIs) and determined the extent of diaschisis by correlative analyses. For the Alzheimer pup, we found cerebellar Ah correlated negatively, and thalamic AIs positively, with those of the cerebral hemisphere and fmntal, temporal, parietal, and angular cortices, while basal ganglia AIs correlated positively with frontal cortical AIs. The only significant correlation of AIs for normal subject a was between the thalamus and cerebral hemisphere. These data indicate that PET is a sensitive technique for detecting diaschisis.