Correlation Between Strain Differences in Susceptibility to Experimental Allergic Encephalomyelitis and the Immune Response to Encephalitogenic Protein in Inbred Guinea Pigs

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Abstract
Differences were observed between guinea pigs of inbred strains 2 and 13 in both the susceptibility to the induction of experimental allergic encephalo-myelitis (EAE), and the immune response to the basic encephalitogen. Strain 2 guinea pigs, which are resistant to the induction of the disease, produce humoral antibodies against the encephalitogen in a titer 40–50-fold higher than guinea pigs of strain 13, which are sensitive to EAE.