A potential iron pharmaceutical composition for the treatment of iron-deficiency anaemia. The crystal and molecular structure of mer-tris-(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III)
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 5,p. 1159-1163
- https://doi.org/10.1039/dt9880001159
Abstract
mer-Tris(3-hydroxy-2-methyl-4H-pyran-4-onato)iron(III) has potential use in the treatment of iron-deficiency anaemia. It displays the ideal properties that a new iron chelation complex must possess to be an effective treatment. These properties are discussed. The crystal and molecular structure of this complex has been determined from single-crystal X-ray diffraction data and refined by least squares to R= 0.0649 for 2 735 independent reflections. The compounds crystallizes in the monoclinic space group P21/c with cell dimensions a= 7.369(1), b= 14.720(3), and c= 19.964(5)Å, β= 100.41(2)°, and Z= 4. The iron atom lies in a distorted octahedral environment with the three ligands bonded through the hydroxy and ketone oxygen atoms to give the mer configuration. Variable-temperature 57Fe Mössbauer data for the complex are reported and the results are discussed in relation to the structure.Keywords
This publication has 2 references indexed in Scilit:
- Crystal and molecular structure of piperidinium μ-acetato-di-μ-1,2-benzenediolato-bis-1,2-benzenediolatoferrate(III), (C5H12N)3 [(CH3COO){Fe(C6H4O2)2}2]: a compound of relevance to the 2Fe-active site of the respiratory protein hemerythrinJournal of Inorganic Biochemistry, 1982
- Coordination isomers of biological iron transport compounds. VI. Models of the enterobactin coordination site. A crystal field effect in the structure of potassium tris(catecholato)chromate(III) and -ferrate(III) sesquihydrates, K3[M(O2C6H4)3].cntdot.1.5H2O, M = chromium, ironJournal of the American Chemical Society, 1976